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You would be considered to be at risk of steroid-induced osteoporosis if you have been taking prednisolone tablets at a dose of 7mg/day for at least 13 weeks. The risk of developing osteoporosis associated with this use of prednisolone tablets is significantly reduced when the total weekly dose of 15 mg/day is reduced to 6.9 mg/day. A controlled trial (10-week randomized, placebo-controlled, double-blind study) of prednisolone tablets in adolescents and young adults with symptomatic idiopathic Parkinson's disease reported reductions in weight, waist circumference and weight loss of 2.3 and 2.7 kg, respectively, compared with patients taking placebo. The authors reported that this study did not show any effect on fracture risk. The overall results of this study did not show an effect on the rate of disability in patients with idiopathic Parkinson's disease. Evidence Safety and effectiveness have been established in two double-blind, crossover studies of prednisolone tablets in healthy adolescents in Canada in 2006 and 2008 (6,10,12,13). Both studies demonstrated the benefit of reduced daily dose of prednisolone tablets during the first two weeks and in week 3 and that the beneficial effects persisted beyond the first 8 weeks despite reduced daily dose (5,6,12,13). In contrast, an uncontrolled, randomized, blinded, double-blind study using a slightly different schedule of administration in adolescents aged 7 to 17 years with symptomatic idiopathic Parkinson's disease failed to show any difference in either the efficacy or safety of prednisolone tablets between the two study groups (5). However, the study showed a nonsignificant increase in bone mineral density for the prednisolone-treated group (P=.11), which was not statistically significant (3). This study also failed to show benefit on bone mineral density, the primary objective of the study (5); therefore, this study was not included in the review. It is important to note that a study of prednisolone tablets was also reported in a meta-analysis that showed significant effect on risk of bone fracture at the level of individuals with symptomatic idiopathic Parkinson's disease in which prednisolone tablets, given once daily for 20 to 32 doses per year, were compared with placebo (14). The meta-analysis also included studies of adolescents and children as young as 6 years (14), including a review of the safety and effectiveness of this drug for the treatment of Parkinson's disease (14). A meta-analysis of the Similar articles: